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Drug Discov Today. 2012 Jan;17(1-2):71-80. doi: 10.1016/j.drudis.2011.09.009. Epub 2011 Sep 18.

Curcumin nanoformulations: a future nanomedicine for cancer.

Author information

  • 1Cancer Biology Research Center, Sanford Research/University of South Dakota, 2301 E. 60th Street North, Sioux Falls, SD 57104, USA. Murali.Yallapu@sanfordhealth.org

Abstract

Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer potential. In this review, we focus on the design and development of nanoparticles, self-assemblies, nanogels, liposomes and complex fabrication for sustained and efficient curcumin delivery. We also discuss the anticancer applications and clinical benefits of nanocurcumin formulations. Only a few novel multifunctional and composite nanosystem strategies offer simultaneous therapy as well as imaging characteristics. We also summarize the challenges to developing curcumin delivery platforms and up-to-date solutions for improving curcumin bioavailability and anticancer potential for therapy.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21959306
[PubMed - indexed for MEDLINE]
PMCID:
PMC3259195
Free PMC Article

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