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Curr Biol. 2011 Sep 27;21(18):R692-5. doi: 10.1016/j.cub.2011.08.018.

Protein degradation: BAGging up the trash.

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  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot¬†76100, Israel.

Abstract

Cells efficiently uncover and degrade proteins that are misfolded. However, we know very little about what cells do to protect themselves from mislocalized proteins. A new study reveals a novel quality control pathway that recognizes and degrades secretory pathway proteins that have failed to target to the endoplasmic reticulum.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21959156
[PubMed - indexed for MEDLINE]
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