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Future Microbiol. 2011 Sep;6(9):1083-98. doi: 10.2217/fmb.11.87.

Human papillomavirus and cervical cancer: biomarkers for improved prevention efforts.

Author information

  • 1Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Blvd EPS 5024, Rockville MD 20852, USA.

Abstract

While organized screening programs in industrialized countries have significantly reduced cervical cancer incidence, cytology-based screening has several limitations. Equivocal or mildly abnormal Pap tests require costly retesting or diagnostic work-up by colposcopy and biopsy. In low-resource countries, it has been difficult to establish and sustain cytology-based programs. Advances in understanding human papillomavirus biology and the natural history of human papillomavirus-related precancers and cancers have led to the discovery of a range of novel biomarkers in the past decade. In this article, we will discuss the potential role of new biomarkers for primary screening, triage and diagnosis in high-resource countries and their promise for prevention efforts in resource constrained settings.

PMID:
21958146
[PubMed - indexed for MEDLINE]
PMCID:
PMC3809085
Free PMC Article

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