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Wiley Interdiscip Rev RNA. 2011 Jul-Aug;2(4):571-81. doi: 10.1002/wrna.77. Epub 2011 Feb 18.

Functions and mechanisms of spliceosomal small nuclear RNA pseudouridylation.

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  • 1Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA.

Abstract

Pseudouridines are the most abundant and highly conserved modified nucleotides identified in spliceosomal small nuclear RNAs (snRNAs). Most pseudouridines are also clustered in functionally important regions of spliceosomal snRNAs. Experiments carried out in several independent experimental systems show that the pseudouridines in spliceosomal snRNAs are functionally important for pre-messenger RNA (mRNA) splicing. Experimental data also indicate that spliceosomal snRNA pseudouridylation can be catalyzed by both RNA-dependent (box H/ACA Ribonucleoproteins) and RNA-independent (protein-only enzymes) mechanisms.

Copyright © 2011 John Wiley & Sons, Ltd.

PMID:
21957045
[PubMed - indexed for MEDLINE]
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