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RNA Biol. 2011 Nov-Dec;8(6):938-46. doi: 10.4161/rna.8.6.16603. Epub 2011 Nov 1.

Animal snoRNAs and scaRNAs with exceptional structures.

Author information

  • 1RNA Bioinformatik Gruppe, Institut f¨ur Pharmazeutische Chemie, Philipps Universit¨at Marburg, Marburg, Germany.

Abstract

The overwhelming majority of small nucleolar RNAs (snoRNAs) fall into two clearly defined classes characterized by distinctive secondary structures and sequence motifs. A small group of diverse ncRNAs, however, shares the hallmarks of one or both classes of snoRNAs but differs substantially from the norm in some respects. Here, we compile the available information on these exceptional cases, conduct a thorough homology search throughout the available metazoan genomes, provide improved and expanded alignments, and investigate the evolutionary histories of these ncRNA families as well as their mutual relationships.

PMID:
21955586
[PubMed - indexed for MEDLINE]
PMCID:
PMC3256416
Free PMC Article

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