Novel rhein analogues as potential anticancer agents

Xiaochuan Yang; Guojing Sun; Chunhao Yang; Binghe Wang

doi:10.1002/cmdc.201100384

Novel rhein analogues as potential anticancer agents

ChemMedChem. 2011 Dec 9;6(12):2294-301. doi: 10.1002/cmdc.201100384. Epub 2011 Sep 26.

Authors

Xiaochuan Yang¹, Guojing Sun, Chunhao Yang, Binghe Wang

Affiliation

¹ Department of Chemistry and Center for Diagnostics and Therapeutics, Georgia State University, 100 Piedmont Ave., Atlanta, GA 30303-4098, USA.

PMID: 21954017
DOI: 10.1002/cmdc.201100384

Abstract

Two series of rhein analogues were synthesized with modification at the 3-position. Their cytotoxicities were evaluated using an MTT assay. Among all the compounds synthesized, one compound showed the best potency, with an IC(50) value of 2.7 μM against the HeLa cell line and 0.6 μM against the MOLT4 cell line.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anthraquinones / chemical synthesis
Anthraquinones / chemistry*
Anthraquinones / pharmacology
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Cell Proliferation / drug effects
Humans
Neoplasms
Structure-Activity Relationship

Substances

1,8-dihydroxy-3-(2'-chloro-acetamido)anthraquinone
Anthraquinones
Antineoplastic Agents
rhein