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J Biomed Opt. 2011 Sep;16(9):095003. doi: 10.1117/1.3622492.

Common-path low-coherence interferometry fiber-optic sensor guided microincision.

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  • 1Johns Hopkins University, Department of Electrical and Computer Engineering, Baltimore, Maryland 21218, USA.


We propose and demonstrate a common-path low-coherence interferometry (CP-LCI) fiber-optic sensor guided precise microincision. The method tracks the target surface and compensates the tool-to-surface relative motion with better than ± 5 μm resolution using a precision micromotor connected to the tool tip. A single-fiber distance probe integrated microdissector was used to perform an accurate 100 μm incision into the surface of an Intralipid phantom. The CP-LCI guided incision quality in terms of depth was evaluated afterwards using three-dimensional Fourier-domain optical coherence tomography imaging, which showed significant improvement of incision accuracy compared to free-hand-only operations.

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