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Ann N Y Acad Sci. 2011 Sep;1232:210-29. doi: 10.1111/j.1749-6632.2011.06053.x.

Barrett's esophagus: progression to adenocarcinoma and markers.

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  • 1South West Hospital, Third Military Medical University, Chongqing, China.


The following on progression to adenocarcinoma and markers of Barrett's esophagus includes commentariess on the expression of claudin 4 in Barrett's adenocarcinoma; the role of acid and bile salts; the role of insulin-like growth factor; the value of reactive oxygen species; the importance of abnormal methylation; genetic alterations in stromal cells and genomic changes in the epithelial cells; the value of confocal laser endomicroscopy for the subsurface analysis of the mucosa; indications for statins as adjuvant chemotherapeutic agent; the sequence of molecular events in malignant progression in Barrett's mucosa; and the value of the macroscopic markers and of p53 mutations.

© 2011 New York Academy of Sciences.

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