Format

Send to:

Choose Destination
See comment in PubMed Commons below
Psychosom Med. 2011 Oct;73(8):638-42. doi: 10.1097/PSY.0b013e3182306a4f. Epub 2011 Sep 23.

Neuroticism, depressive symptoms, and serum BDNF.

Author information

  • 1National Institute on Aging, National Institutes of Health, Department of Health and Human Services, 251 Bayview Blvd, Baltimore, MD 21224, USA. Terraccianoa@mail.nih.gov

Abstract

OBJECTIVE:

Animal models and clinical studies suggest that brain-derived neurotrophic factor (BDNF) is involved in the pathophysiology of depression. We test whether serum and plasma levels of BDNF are associated with trait neuroticism and its facets and with state measures of depressive symptoms.

METHODS:

In a community-based cohort (N = 2099), we measured serum and plasma BDNF concentrations and administered the Revised NEO Personality Inventory and the Center for Epidemiological Studies Depression Scale. Covariates included age, sex, cigarette smoking, obesity, and antidepressant use.

RESULTS:

Serum BDNF concentrations were inversely related to neuroticism (r = -0.074, p < .001), in particular the depression facet (r = -0.08, p < .001). Lower BDNF concentrations were also associated with severe depressive symptoms (Center for Epidemiological Studies Depression Scale ≥ 28; odds ratio = 0.906; 95% confidence interval = 0.851-0.965). The association of serum BDNF with neuroticism was independent of depressive symptoms, indicating that serum BDNF might represent a biological correlate of neuroticism and not just of transient depressive states. Plasma BDNF was not associated with measures of depression.

CONCLUSIONS:

Our study suggests that lower serum BDNF is associated with both a dispositional vulnerability to depression and acute depressive states in the general population.

PMID:
21949427
[PubMed - indexed for MEDLINE]
PMCID:
PMC3188695
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Lippincott Williams & Wilkins Icon for PubMed Central
    Loading ...
    Write to the Help Desk