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    Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17201-6. doi: 10.1073/pnas.1114241108. Epub 2011 Sep 26.

    TrkB signaling in parvalbumin-positive interneurons is critical for gamma-band network synchronization in hippocampus.

    Zheng K, An JJ, Yang F, Xu W, Xu ZQ, Wu J, Hökfelt TG, Fisahn A, Xu B, Lu B.

    Source

    Gene, Cognition and Psychosis Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-3714, USA.

    Abstract

    Although brain-derived neurotrophic factor (BDNF) is known to regulate circuit development and synaptic plasticity, its exact role in neuronal network activity remains elusive. Using mutant mice (TrkB-PV(-/-)) in which the gene for the BDNF receptor, tyrosine kinase B receptor (trkB), has been specifically deleted in parvalbumin-expressing, fast-spiking GABAergic (PV+) interneurons, we show that TrkB is structurally and functionally important for the integrity of the hippocampal network. The amplitude of glutamatergic inputs to PV+ interneurons and the frequency of GABAergic inputs to excitatory pyramidal cells were reduced in the TrkB-PV(-/-) mice. Functionally, rhythmic network activity in the gamma-frequency band (30-80 Hz) was significantly decreased in hippocampal area CA1. This decrease was caused by a desynchronization and overall reduction in frequency of action potentials generated in PV+ interneurons of TrkB-PV(-/-) mice. Our results show that the integration of PV+ interneurons into the hippocampal microcircuit is impaired in TrkB-PV(-/-) mice, resulting in decreased rhythmic network activity in the gamma-frequency band.

    PMID:
    21949401
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3193255
    Free PMC Article

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