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Clin Cancer Res. 2011 Nov 1;17(21):6605-7. doi: 10.1158/1078-0432.CCR-11-2240. Epub 2011 Sep 26.

Is it downhill from here? Eliminating leukemic stem cells and curing chronic myeloid leukemia.

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  • 1Division of Hematology-Oncology, Department of Medicine, University of California at San Francisco, San Francisco, California 94143, USA.


Patients with chronic phase chronic myeloid leukemia who respond to imatinib have a rapid initial decrease in BCR-ABL transcript levels (α), followed by a slow decline (β). The rate of β decrease is consistent with declining leukemic stem cells and may predict which patients may safely discontinue therapy.

©2011 AACR

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