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Bull Environ Contam Toxicol. 2011 Dec;87(6):638-42. doi: 10.1007/s00128-011-0400-2. Epub 2011 Sep 27.

The effect of N-nitrosodimethylamine (NDMA) on Bax and Mcl-1 expression in human neutrophils.

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  • 1Department of Toxicology, Medical University of Bialystok, Mickiewicza 2c, 15-222, Bialystok, Poland. toksykologia@wp.pl

Abstract

In the present study we examined a role of pro-apoptotic Bax and anti-apoptotic Mcl-1 proteins, participating in the regulation of intrinsic apoptosis pathway in human neutrophils (PMNs) exposed to N-nitrosodimethylamine (NDMA), the environmental xenobiotic. For the purpose comparison, the same studies were conducted in autologous peripheral blood mononuclear cells (PBMCs). The production of cytochrome c by PMNs was also determined. A deficit of anti-apoptotic Mcl-1 and overexpression of the pro-apoptotic protein Bax suggest that the apoptosis process in human neutrophils exposed to NDMA is dependent on changes in the expression of these proteins. PMNs were more sensitive to NDMA than PBMCs.

PMID:
21947543
[PubMed - indexed for MEDLINE]
PMCID:
PMC3223349
Free PMC Article

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