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Arch Gynecol Obstet. 2012 Apr;285(4):1157-60. doi: 10.1007/s00404-011-2089-1. Epub 2011 Sep 25.

Endometrial adenocarcinoma with osteoclastic giant cells in stroma: a case report and review of literature.

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  • 1The Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh, 202002 UP, India.


It is rare to find osteoclastic giant cells (OGCs) as a stromal reaction in uterine adenocarcinoma of endometrium. Here, we report a case of a 60-year-old female diagnosed with adenocarcinoma of endometrium. Total hysterectomy with bilateral salpingo-oopherectomy and removal of pelvic lymphnodes was performed. Histologically, the tumour showed adenocarcinoma of the endometrium with mucin secretion. The stroma showed some plump reactive pleomorphic cells, resembling stromal cells, infiltrated uniformly with OGCs and mononuclear cells (MNCs). The epithelial cells of adenocarcinoma stained positive for cytokeratin (CK 7) (CAM 5.2). The osteoclastic giant cells and mononuclear cells stained positive with CD68 and negative with cytokeratin and vimentin. We conclude that the osteoclastic giant cells originated from reactive histiocytes/monocytes as a stromal reaction to malignancy.

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