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Infect Genet Evol. 2012 Jun;12(4):866-72. doi: 10.1016/j.meegid.2011.09.004. Epub 2011 Sep 14.

European 2--a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula.

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  • 1Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, 28040 Madrid, Spain. sabrina.rodriguez@visavet.ucm.es

Abstract

Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles.

Copyright © 2011 Elsevier B.V. All rights reserved.

PMID:
21945286
[PubMed - indexed for MEDLINE]
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