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    Infect Genet Evol. 2012 Jun;12(4):866-72. doi: 10.1016/j.meegid.2011.09.004. Epub 2011 Sep 14.

    European 2--a clonal complex of Mycobacterium bovis dominant in the Iberian Peninsula.

    Rodriguez-Campos S, Schürch AC, Dale J, Lohan AJ, Cunha MV, Botelho A, De Cruz K, Boschiroli ML, Boniotti MB, Pacciarini M, Garcia-Pelayo MC, Romero B, de Juan L, Domínguez L, Gordon SV, van Soolingen D, Loftus B, Berg S, Hewinson RG, Aranaz A, Smith NH.

    Source

    Centro de Vigilancia Sanitaria Veterinaria (VISAVET), Universidad Complutense de Madrid, 28040 Madrid, Spain. sabrina.rodriguez@visavet.ucm.es

    Abstract

    Mycobacterium bovis isolates from the Iberian Peninsula are dominated by strains with spoligotype patterns deleted for spacer 21. Whole-genome sequencing of three Spanish strains with spacer 21 missing in their spoligotype pattern revealed a series of SNPs and subsequent screening of a selection of these SNPs identified one in gene guaA that is specific to these strains. This group of strains from the Iberian Peninsula missing spoligotype spacer 21 represents a new clonal complex of M. bovis, defined by the SNP profile with a distinct spoligotype signature. We have named this clonal complex European 2 (Eu2) and found that it was present at low frequency in both France and Italy and absent from the British Isles.

    Copyright © 2011 Elsevier B.V. All rights reserved.

    PMID:
    21945286
    [PubMed - indexed for MEDLINE]

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