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J Urol. 2011 Nov;186(5):1825-9. doi: 10.1016/j.juro.2011.06.055. Epub 2011 Sep 25.

Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer.

Author information

  • 1Department of Urology, UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94143-1695, USA. sporten@urology.ucsf.edu

Abstract

PURPOSE:

We described changes in tumor volume on serial biopsies during an extended period in men on active surveillance.

MATERIALS AND METHODS:

The study cohort included men diagnosed with prostate cancer between 1998 and 2010 enrolled in active surveillance with 6 or more months of followup. Change in volume over time was assessed as change in percent cores positive, percent cancer in 1 biopsy core and the doubling of total cancer volume (mm). Logistic regression was used to determine the association between grade and volume progression.

RESULTS:

A total of 399 men met the study inclusion criteria. Mean patient age was 61.8 years old and 313 (78%) had low risk disease. Overall 231 (58%) men had stable disease on repeat biopsies. There were 39 (10%) men with a volume increase, defined by an increase to more than 33% cores involved or an increase in maximum single core positive to more than 50%, and there were 44 (11%) with an increase in volume and grade. Approximately 10% of men experienced a decrease in cancer volume. On multivariate analysis there was a significant association between grade and volume progression on any biopsy (OR 3.07), and a doubling of tumor length (mm) at 5 years (OR 6.30).

CONCLUSIONS:

Prostate cancer volume increases and decreases at a similar rate of 10% per biopsy. An increase in tumor volume is associated with an increase in cancer grade on early repeat biopsies. However, there is a large degree of variation in cancer volume over time.

Copyright © 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

PMID:
21944082
[PubMed - indexed for MEDLINE]
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