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Cancer Lett. 2011 Dec 22;312(2):150-7. doi: 10.1016/j.canlet.2011.07.028. Epub 2011 Aug 22.

Identification of the bleomycin hydrolase gene as a methylated tumor suppressor gene in hepatocellular carcinoma using a novel triple-combination array method.

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  • 1Department of Surgery II, Graduate School and Medicine, University of Nagoya, Showa-ku, Japan.


In the present study, we sought to identify novel suppressor genes of hepatocellular carcinoma (HCC) using our newly designed triple-combination array. Using this method, the bleomycin hydrolase gene (BLMH) was detected as a candidate suppressor gene. We found that 28 of 48 (58.3%) tumor tissues showed BLMH promoter hypermethylation, and its expression level was significantly reduced in tumor tissues (P=0.001). The present study suggests that our new method can detect novel genes of interest and that BLMH is a suppressor gene in HCC.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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