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Neuron. 2011 Sep 22;71(6):955-7. doi: 10.1016/j.neuron.2011.09.002. Epub 2011 Sep 21.

Wnt signaling as a potential therapeutic target for frontotemporal dementia.

Author information

  • 1Department of Psychiatry and Vanderbilt Kennedy Center for Research on Human Development, Vanderbilt University, Nashville, TN 37232, USA. zeljka.korade@vanderbilt.edu

Abstract

Progranulin mutations result in frontotemporal dementia, but the underlying pathophysiology has remained largely unexplained. New data by Geschwind and colleagues in this issue of Neuron uncovered that the Wnt/FZD2 signaling pathway is an early and critical contributor to disease pathology.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21943593
[PubMed]
PMCID:
PMC3183459
Free PMC Article
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