Ubiquitin-conjugating enzymes: novel regulators of...[Trends Biochem Sci. 1990]

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1: Trends Biochem Sci. 1990 May;15(5):195-8.Links

Ubiquitin-conjugating enzymes: novel regulators of eukaryotic cells.

Jentsch S, Seufert W, Sommer T, Reins HA.

Friedrich-Miescher-Laboratory, Max-Planck-Society, Tübingen, FRG.

Covalent attachment of ubiquitin to cellular proteins is essential for cell viability and is catalysed by a set of distinct ubiquitin-conjugating enzymes. Individual members of this novel enzyme family mediate strikingly diverse functions, including DNA repair, cell cycle control, selective protein degradation and essential functions of the stress response.

PMID: 2193438 [PubMed - indexed for MEDLINE]

UBC1 encodes a novel member of an essential subfamily of yeast ubiquitin-conjugating enzymes involved in protein degradation.
EMBO J. 1990 Dec; 9(13):4535-41.

[EMBO J. 1990]
ReviewYeast ubiquitin-conjugating enzymes involved in selective protein degradation are essential for cell viability.
Acta Biol Hung. 1991; 42(1-3):27-37.

[Acta Biol Hung. 1991]
ReviewNedd4-like proteins: an emerging family of ubiquitin-protein ligases implicated in diverse cellular functions.
Trends Cell Biol. 1999 May; 9(5):166-9.

[Trends Cell Biol. 1999]
ReviewUbiquitin system: selectivity and timing of protein destruction.
J Biochem. 1999 Feb; 125(2):223-9.

[J Biochem. 1999]
Isolation, characterization, and partial purification of a novel ubiquitin-protein ligase, E3. Targeting of protein substrates via multiple and distinct recognition signals and conjugating enzymes.
J Biol Chem. 1996 Jan 5; 271(1):302-10.

[J Biol Chem. 1996]
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Cited by 38 PubMed Central articles

Functional diversification of duplicate genes through subcellular adaptation of encoded proteins.
Marques AC, Vinckenbosch N, Brawand D, Kaessmann H. Genome Biol. 2008; 9(3):R54. Epub 2008 Mar 12.

[Genome Biol. 2008]
Saccharomyces cerevisiae Ub-conjugating enzyme Ubc4 binds the proteasome in the presence of translationally damaged proteins.
Chuang SM, Madura K. Genetics. 2005 Dec; 171(4):1477-84. Epub 2005 Aug 22.

[Genetics. 2005]
The checkpoint protein Chfr is a ligase that ubiquitinates Plk1 and inhibits Cdc2 at the G2 to M transition.
Kang D, Chen J, Wong J, Fang G. J Cell Biol. 2002 Jan 21; 156(2):249-59. Epub 2002 Jan 21.

[J Cell Biol. 2002]
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