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J Infect Dis. 2011 Nov;204(9):1391-4. doi: 10.1093/infdis/jir536. Epub 2011 Sep 20.

Genetic polymorphism in IL28B is associated with spontaneous clearance of hepatitis C virus genotype 4 infection in an Egyptian cohort.

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  • 1Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.

Abstract

Single-nucleotide polymorphisms (SNPs) around IL28B are associated with spontaneous hepatitis C virus (HCV) clearance of genotypes 1 and 3 in white and African-American populations. This study investigated whether the IL28B SNP (rs12979860) is associated with spontaneous clearance of HCV, principally genotype 4, in 162 Egyptians (80 with clearance). The protective C allele was more common in those with spontaneous clearance (76.3% vs 57.9%; P = .0006). Individuals with clearance were 3.4 (95% confidence interval, 1.8-6.5) times more likely to have C/C genotype. Thus, IL28B plays a role in spontaneous clearance of HCV genotype 4 in North Africa.

PMID:
21933876
[PubMed - indexed for MEDLINE]
PMCID:
PMC3182308
Free PMC Article
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