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Radiology. 2011 Oct;261(1):1-2. doi: 10.1148/radiol.11111636.

Science to practice: can theranostic fullerenes be used to treat brain tumors?

Author information

  • Department of Radiology The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. jwmbulte@mri.jhu.edu

Abstract

In an orthotopic brain tumor mouse model, it was shown that convection-enhanced intratumoral delivery of a theranostic metallofullerene (f-Gd₃N@C₈₀) labeled with lutetium 177 (¹⁷⁷Lu) and tetraazacyclododecane tetraacetic acid (DOTA) (¹⁷⁷Lu-DOTA-f-Gd₃N@C₈₀) increases median survival from 21 to 52 days, with a prolonged metallofullerene tumor retention that can be visualized with magnetic resonance (MR) imaging.

© RSNA, 2011.

PMID:
21931135
[PubMed - indexed for MEDLINE]
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