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Arch Surg. 2011 Sep;146(9):1052-9. doi: 10.1001/archsurg.2011.218.

Outcomes with split liver transplantation in 106 recipients: the University of California, San Francisco, experience from 1993 to 2010.

Author information

  • 1Division of Transplant Surgery, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA. parsia.vagefi@ucsfmedctr.org

Abstract

BACKGROUND:

Split liver transplantation (SLT) allows for expansion of the deceased donor pool.

OBJECTIVES:

To assess outcomes and the impact of splitting technique (in situ vs ex vivo) in SLT recipients.

DESIGN:

Single-center retrospective review (September 18, 1993, to July 1, 2010).

SETTING:

University medical center.

PATIENTS:

One hundred six SLT recipients.

MAIN OUTCOME MEASURES:

Postoperative graft and patient survival and postoperative complications.

RESULTS:

In adults, 1-, 5-, and 10-year overall patient survival was 93%, 77%, and 73%, respectively; overall graft survival was 89%, 76%, and 65%, respectively; ex vivo split patient survival was 93%, 85%, and 74%, respectively; and ex vivo graft survival was 86%, 77%, and 63%, respectively. In situ split patient and graft survival was 94% at 1 year and 75% at 5 years. Postoperative complications included biliary (29%), vascular (11%), unplanned reexploratory surgery (11%), incisional hernia (8%), small-for-size syndrome (n = 1), need for shunt at the time of SLT (n = 1), and primary nonfunction (n = 1). In children, 1-, 5-, and 10-year overall patient survival was 84%, 75%, and 69%, respectively; overall graft survival was 77%, 63%, and 57%, respectively; ex vivo split patient survival was 83%, 73%, and 73%, respectively; and ex vivo graft survival was 75%, 59%, and 59%, respectively. In situ split patient and graft survival was 86% at 1 and 5 years. Postoperative complications included biliary (40%), vascular (26%), and primary nonfunction (n = 1).

CONCLUSIONS:

Split liver transplantation remains an excellent option for expansion of the deceased donor pool for adult and pediatric populations. Postoperative morbidity remains high; however, this is justifiable owing to limited resources.

Comment in

PMID:
21931003
[PubMed - indexed for MEDLINE]
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