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Nat Struct Mol Biol. 2011 Sep 18;18(10):1175-7. doi: 10.1038/nsmb.2119.

Crystal structure of a monomeric retroviral protease solved by protein folding game players.

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  • 1Department of Biochemistry, University of Washington, Seattle, Washington, USA.

Erratum in

  • Nat Struct Mol Biol. 2012 Mar;19(3):364.


Following the failure of a wide range of attempts to solve the crystal structure of M-PMV retroviral protease by molecular replacement, we challenged players of the protein folding game Foldit to produce accurate models of the protein. Remarkably, Foldit players were able to generate models of sufficient quality for successful molecular replacement and subsequent structure determination. The refined structure provides new insights for the design of antiretroviral drugs.

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