Format

Send to:

Choose Destination
See comment in PubMed Commons below
Curr Opin Nephrol Hypertens. 2011 Nov;20(6):631-9. doi: 10.1097/MNH.0b013e32834b8850.

Cystatin C as a marker of glomerular filtration rate: prospects and limitations.

Author information

  • 1Tufts Medical Center, Boston, Massachusetts 02111, USA. LInker@tuftsmedicalcenter.org

Abstract

PURPOSE OF REVIEW:

There is much interest in cystatin C to replace or supplement serum creatinine to estimate the glomerular filtration rate (GFR). Here we review the performance of cystatin C and combined creatinine-cystatin C estimating equations compared to creatinine-based estimating equations in chronic and acute kidney disease.

RECENT FINDINGS:

Drift in the cystatin C assay has had a large effect on the results reported using cystatin C, but these issues are not routinely considered in evaluation of GFR-estimating equations. The recently released primary reference material for cystatin C will allow less difference among assays in the future. There does not appear to be a consistent message among published studies as to whether cystatin C-based equations are better than creatinine-based equations in the general population or those with chronic kidney disease (CKD), as well as those with reduced muscle mass or chronic illness, or acute kidney injury. Cystatin C could be used in combination with creatinine as a confirmatory test for estimated GFR from creatinine.

SUMMARY:

Cystatin C may have a role to estimate GFR in selected circumstances, and the next set of studies should be directed at developing implementation strategies for its use.

PMID:
21926620
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Lippincott Williams & Wilkins
    Loading ...
    Write to the Help Desk