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Mol Cell. 2011 Sep 16;43(6):915-26. doi: 10.1016/j.molcel.2011.08.023.

Engineering biological systems with synthetic RNA molecules.

Author information

  • 1Division of Chemistry and Chemical Engineering, 1200 E. California Boulevard, MC 210-41, California Institute of Technology, Pasadena, CA 91125, USA.

Abstract

RNA molecules play diverse functional roles in natural biological systems. There has been growing interest in designing synthetic RNA counterparts for programming biological function. The design of synthetic RNA molecules that exhibit diverse activities, including sensing, regulatory, information processing, and scaffolding activities, has highlighted the advantages of RNA as a programmable design substrate. Recent advances in implementing these engineered RNA molecules as key control elements in synthetic genetic networks are highlighting the functional relevance of this class of synthetic elements in programming cellular behaviors.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21925380
[PubMed - indexed for MEDLINE]
PMCID:
PMC3176441
Free PMC Article

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