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Cell. 2011 Sep 16;146(6):859-60. doi: 10.1016/j.cell.2011.08.026.

SIP-ing the elixir of youth.

Author information

  • 1The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. wmair@hsph.harvard.edu


AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity.

Copyright © 2011 Elsevier Inc. All rights reserved.

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