Cell. 2011 Sep 16;146(6):859-60. doi: 10.1016/j.cell.2011.08.026.

SIP-ing the elixir of youth.

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The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. wmair@hsph.harvard.edu

Abstract

AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity.

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Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. [Cell. 2011]
Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction.Lu JY, Lin YY, Sheu JC, Wu JT, Lee FJ, Chen Y, Lin MI, Chiang FT, Tai TY, Berger SL, et al. Cell. 2011 Sep 16; 146(6):969-79. Epub 2011 Sep 9.

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SIP-ing the elixir of youth.
SIP-ing the elixir of youth.
Cell. 2011 Sep 16 ;146(6):859-60. doi: 10.1016/j.cell.2011.08.026.

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