Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Adv Cancer Res. 2011;112:77-126. doi: 10.1016/B978-0-12-387688-1.00004-1.

Nuclear remodeling as a mechanism for genomic instability in cancer.

Author information

  • 1The University of Manitoba, Manitoba Institute of Cell Biology, Cancer Care Manitoba, The Genomic Centre for Cancer Research and Diagnosis, Winnipeg, Manitoba, Canada.

Abstract

This chapter focuses on the three-dimensional organization of the nucleus in normal, early genomically unstable, and tumor cells. A cause-consequence relationship is discussed between nuclear alterations and the resulting genomic rearrangements. Examples are presented from studies on conditional Myc deregulation, experimental tumorigenesis in mouse plasmacytoma, nuclear remodeling in Hodgkin's lymphoma, and in adult glioblastoma. A model of nuclear remodeling is proposed for cancer progression in multiple myeloma. Current models of nuclear remodeling are described, including our model of altered nuclear architecture and the onset of genomic instability.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID:
21925302
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk