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Psychiatry Res. 2011 Nov 30;194(2):184-9. doi: 10.1016/j.pscychresns.2011.04.008. Epub 2011 Sep 15.

Cellular pathology within the anterior cingulate cortex of patients with late-life depression: a morphometric study.

Author information

  • 1Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK. ahmad.khundakar@newcatle.ac.uk


Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.

Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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