Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
Am J Surg. 2012 Feb;203(2):198-204. doi: 10.1016/j.amjsurg.2011.05.012. Epub 2011 Sep 14.

Prestorage leukoreduction abrogates the detrimental effect of aging on packed red cells transfused after trauma: a prospective cohort study.

Author information

  • 1Department of Surgery, Division of Burns/Trauma/Critical Care, University of Texas Southwestern Medical School, Dallas, USA. herb.phelan@utsouthwestern.edu

Abstract

BACKGROUND:

The aim of this study was to prospectively duplicate previous retrospective findings showing that prestorage leukoreduction blunts the detrimental effect of aging on banked packed red blood cells transfused after injury.

METHODS:

Over 19 months, trauma patients transfused with ≥4 U of packed red blood cells and surviving ≥24 hours were followed. The age of each unit was collected.

RESULTS:

The cohort consisted of 153 patients. All models showed no association between advancing blood age and the likelihood of developing multiple-organ dysfunction syndrome or infections, regardless of whether the mean age of blood was analyzed as a continuous variable, as a percentage of blood received that was <14 days old, or as a dichotomized value >14 or <14 days old.

CONCLUSIONS:

This prospective study duplicates previous retrospective findings of an abrogation of the detrimental effects of advancing mean packed red blood cell age on outcomes after trauma by performing prestorage leukoreduction.

Copyright © 2012 Elsevier Inc. All rights reserved.

PMID:
21924400
[PubMed - indexed for MEDLINE]
PMCID:
PMC3243822
Free PMC Article

Images from this publication.See all images (2)Free text

Fig 1
Fig 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk