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BMC Microbiol. 2011 Sep 16;11:203. doi: 10.1186/1471-2180-11-203.

Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering.

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  • 1Mycotic Diseases Branch, Center for Disease Control and Prevention, 1600 Clifton Rd NE, Atlanta, GA 30329, USA.

Abstract

BACKGROUND:

Aspergillus terreus causes invasive aspergillosis (IA) in immunocompromised individuals and can be the leading cause of IA in certain medical centers. We examined a large isolate collection (n = 117) for the presence of cryptic A. terreus species and employed a genome scanning method, Inter-Simple Sequence Repeat (ISSR) PCR to determine A. terreus population structure.

RESULTS:

Comparative sequence analyses of the calmodulin locus revealed the presence of the recently recognized species A. alabamensis (n = 4) in this collection. Maximum parsimony, Neighbor joining, and Bayesian clustering of the ISSR data from the 113 sequence-confirmed A. terreus isolates demonstrated that one clade was composed exclusively of isolates from Europe and another clade was enriched for isolates from the US.

CONCLUSIONS:

This study provides evidence of a population structure linked to geographical origin in A. terreus.

PMID:
21923908
[PubMed - indexed for MEDLINE]
PMCID:
PMC3197500
Free PMC Article
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