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Int J Alzheimers Dis. 2011;2011:537528. doi: 10.4061/2011/537528. Epub 2011 Sep 14.

Issues raised involving the copper hypotheses in the causation of Alzheimer's disease.

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  • 1Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA.


I present evidence that the epidemic of Alzheimer's disease is a new phenomenon exploding in the latter part of the 20th century in developed countries. I postulate that a major causative factor in the epidemic is the coincident use of copper plumbing, and the ingestion of inorganic copper leaching from the copper plumbing. I present evidence to support this hypothesis and discuss various objections and criticisms that have been raised about the hypothesis, and my responses to these criticisms. I conclude that the hypothesis is well supported by the evidence and deserves serious consideration, because if it is valid, it indentifies a partially preventable cause of Alzheimer's disease.

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