EMBO Rep. 2011 Oct 28;12(11):1167-74. doi: 10.1038/embor.2011.178.

A genetic in vivo system to detect asymmetrically distributed RNA.

JayaNandanan N, Gavis ER, Riechmann V, Leptin M.

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Institute of Genetics, University of Cologne, Zülpicher Strasse 47, Cologne 50674, Germany.

Abstract

Many RNAs show polarized or otherwise non-random subcellular distributions. To create a method for genome-wide genetic screens for RNAs with asymmetric subcellular distributions, we have combined methods for gene tagging and live imaging of messenger RNA (mRNA). A pilot screen in a highly polarized, differentiated cell in the Drosophila larva, the branched terminal cell of the tracheal system, demonstrates the feasibility of the method for identifying new asymmetrically localized mRNAs in vivo.

PMID:: 21921935; [PubMed - indexed for MEDLINE]
PMCID:: PMC3207103; [Available on 2012/11/1]

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