Infusionstherapie. 1990 Apr;17(2):108-12.

Energy expenditure in the obese: is there a thrifty gene?

Source

Clinical Diabetes and Nutrition Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, Arizona.

Abstract

Seven to eight thousand Pima Indians are presently living in the southwestern desert of Arizona. The prevalence of type II diabetes in this population exceeds 45% and more than 75% of the Pimas are obese. In 1962, Neel proposed that obesity in populations like the Pima Indians might be the expression of a "thrifty gene" which becomes detrimental with progress. Since 1982, longitudinal studies have been conducted including measurements of metabolic rate in 200 non-diabetic Pima Indians and have shown that 1) at any given body weight and body composition, there is quite a large variability in the resting metabolic rate which is not accounted for by intra-individual variability or errors of the methods; 2) metabolic rate after adjustment for body composition and body weight is a familial trait; 3) a low metabolic rate is a risk factor for body weight gain; 4) in response to body weight gain, there is a "normalization" of the resting metabolic rate. These studies are the first showing that a "thrifty" metabolic rate can play a role in the development of obesity.

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Review Energy metabolism in obesity. Studies in the Pima Indians. [Diabetes Care. 1993]
Review Energy metabolism in obesity. Studies in the Pima Indians.
Ravussin E. Diabetes Care. 1993 Jan; 16(1):232-8.
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Cited by 5 PubMed Central articles

Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians. [Diabetes. 2010]
Variants in ASK1 are associated with skeletal muscle ASK1 expression, in vivo insulin resistance, and type 2 diabetes in Pima Indians.
Bian L, Hanson RL, Ossowski V, Wiedrich K, Mason CC, Traurig M, Muller YL, Kobes S, Knowler WC, Baier LJ, et al. Diabetes. 2010 May; 59(5):1276-82. Epub 2010 Feb 25.
The Thrsp null mouse (Thrsp(tm1cnm)) and diet-induced obesity. [Mol Cell Endocrinol. 2009]
The Thrsp null mouse (Thrsp(tm1cnm)) and diet-induced obesity.
Anderson GW, Zhu Q, Metkowski J, Stack MJ, Gopinath S, Mariash CN. Mol Cell Endocrinol. 2009 Apr 10; 302(1):99-107. Epub 2009 Jan 20.
PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians. [Diabetes. 2008]
PCLO variants are nominally associated with early-onset type 2 diabetes and insulin resistance in Pima Indians.
Ma L, Hanson RL, Que LN, Guo Y, Kobes S, Bogardus C, Baier LJ. Diabetes. 2008 Nov; 57(11):3156-60. Epub 2008 Jul 22.

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