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Sci Signal. 2011 Sep 6;4(190):tr4. doi: 10.1126/scisignal.2001966.

Introduction to statistical methods for analyzing large data sets: gene-set enrichment analysis.

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  • 1Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

Abstract

This Teaching Resource provides lecture notes, slides, and a problem set for a series of lectures introducing the mathematical concepts behind gene-set enrichment analysis (GSEA) and were part of a course entitled "Systems Biology: Biomedical Modeling." GSEA is a statistical functional enrichment analysis commonly applied to identify enrichment of biological functional categories in sets of ranked differentially expressed genes from genome-wide mRNA expression data sets.

PMID:
21917718
[PubMed - indexed for MEDLINE]
PMCID:
PMC3205944
Free PMC Article
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