Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Heart. 2011 Nov;97(22):1828-33. doi: 10.1136/heartjnl-2011-300343. Epub 2011 Sep 13.

Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal.

Author information

  • 1Department of Internal Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy. fpperron@unina.it


Cardiac sympathetic activity can be assessed by (123)I-labelled meta-iodobenzylguanidine (MIBG) scintigraphy. Abnormalities of sympathetic cardiac activity have been shown in patients with heart failure, resulting in reduced MIBG uptake. Abnormal MIBG uptake predicts cardiac death, arrhythmias and all-cause mortality in patients with heart failure with a prognostic power incremental to that of conventional risk markers, and may identify patients at low risk of arrhythmias despite current guideline indications for implantable cardioverter defibrillator or patients at high risk for arrhythmias not fulfilling implantable cardioverter defibrillator indications. Prospective outcome studies are needed to assess whether MIBG imaging will have an impact on the mortality and morbidity of patients with heart failure.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk