Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Bioessays. 2011 Nov;33(11):830-9. doi: 10.1002/bies.201100084. Epub 2011 Sep 14.

Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs.

Author information

  • 1Omics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro Cho, Tsurumi Ku, Yokohama, Kanagawa 230-0045, Japan.

Abstract

Common themes are emerging in the molecular mechanisms of long non-coding RNA-mediated gene repression. Long non-coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of genes into silent compartments. The similarities suggest that these are fundamental processes of transcription regulation governed by lncRNAs. These findings have paved the way for analogous investigations on other lncRNAs and chromatin remodelling enzymes. Here we discuss these common mechanisms and provide our view on other molecules that warrant similar investigations. We also present our concepts on the possible mechanisms that may facilitate the exit of genes from the silencing domains and their potential therapeutic applications. Finally, we point to future areas of research and put forward our recommendations for improvements in resources and applications of existing technologies towards targeted outcomes in this active area of research.

Copyright © 2011 WILEY Periodicals, Inc.

PMID:
21915889
[PubMed - indexed for MEDLINE]
PMCID:
PMC3258546
Free PMC Article

Images from this publication.See all images (2)Free text

Figure 1
Figure 2
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc. Icon for PubMed Central
    Loading ...
    Write to the Help Desk