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Pediatr Infect Dis J. 2011 Oct;30(10):887-90. doi: 10.1097/INF.0b013e3182311343.

The use of antimicrobial agents in children with fever during chemotherapy-induced neutropenia: the importance of risk stratification.

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  • 1Section of Infectious Diseases, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.


Children with fever and chemotherapy-induced or cancer-associated neutropenia should be assessed with complete history and physical examinations, undergo appropriate diagnostic studies, and promptly receive broad-spectrum empirical antimicrobial therapy. Assessment of risk for severe infection is crucial in determining the appropriate antimicrobial, route, venue, and duration of empirical antimicrobial therapy and need for prophylactic antimicrobial agents.

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