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    BMC Biochem. 2011 Sep 13;12:50.

    Regulation of the BRCA1 gene by an SRC3/53BP1 complex.

    Corkery D, Thillainadesan G, Coughlan N, Mohan RD, Isovic M, Tini M, Torchia J.

    Source

    Department of Oncology, London Regional Cancer Program and Lawson Health Research Institute, 790 Commissioners Rd, London, Ontario N6A 4L6 Canada.

    Abstract

    BACKGROUND:

    Steroid Receptor coactivator 3(SRC3) is an oncogene and a member of the SRC family of nuclear receptor coactivator proteins that mediate the transcriptional effects of nuclear hormone receptors as well as other transcription factors.

    RESULTS:

    We have used protein purification and mass spectrometry to identify the 53BP1 tumour suppressor as a novel SRC3-associated protein. Copurification was demonstrated using multiple antibodies, and was not dependent on DNA damage suggesting that SRC3 is not directly involved in the DNA damage response. However using chromatin immunoprecipitation(ChIP) and siRNA knockdown, we have demonstrated that both SRC3 and 53BP1 co-occupy the same region of the BRCA1 promoter and both are required for BRCA1 expression in HeLa cells.

    CONCLUSIONS:

    Our results suggest that both 53BP1 and SRC3 have a common function that converge at the BRCA1 promoter and possibly other genes important for DNA repair and genomic stability.

    PMID:
    21914189
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC3180649
    Free PMC Article

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