[Comparison of VEGF, IL-8 and beta-FGF concentrations in the serum and ascites of patients with ovarian cancer]

Ginekol Pol. 2011 Jul;82(7):498-502.
[Article in Polish]

Abstract

Epithelial ovarian cancer is the leading cause of cancer death from gynecological malignancies. Angiogenesis is considered essential for tumor growth and the development of metastases. VEGF, IL-8, beta-FGF are potent angiostimulatory molecules and their expression has been demonstrated in many solid tumors, including ovarian cancer. The aim of this study was to compare the levels of VEGF, IL-8 and beta-FGF in the serum and ascites of patients with ovarian cancer VEGF, IL-8, beta-FGF concentrations were measured by ELISA (Quantikine R&D). The median VEGF, IL-8 and beta-FGF levels were significantly higher in the ascites than sera of ovarian cancer patient. VEGF, IL-8, beta-FGF levels in ascites might be regarded as an additional tool in the diagnosis of ovarian cancer.

Publication types

  • Comparative Study

MeSH terms

  • Ascitic Fluid / chemistry*
  • Biomarkers, Tumor / metabolism*
  • Carcinoma, Ovarian Epithelial
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fibroblast Growth Factor 2 / metabolism*
  • Humans
  • Interleukin-8 / metabolism*
  • Neoplasms, Glandular and Epithelial / metabolism*
  • Ovarian Neoplasms / metabolism*
  • Prognosis
  • Vascular Endothelial Growth Factor A / metabolism*
  • Women's Health

Substances

  • Biomarkers, Tumor
  • Interleukin-8
  • Vascular Endothelial Growth Factor A
  • Fibroblast Growth Factor 2