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Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17257-62. doi: 10.1073/pnas.1113249108. Epub 2011 Sep 12.

Dynamics and control of state-dependent networks for probing genomic organization.

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  • 1Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109, USA.

Abstract

A state-dependent dynamic network is a collection of elements that interact through a network, whose geometry evolves as the state of the elements changes over time. The genome is an intriguing example of a state-dependent network, where chromosomal geometry directly relates to genomic activity, which in turn strongly correlates with geometry. Here we examine various aspects of a genomic state-dependent dynamic network. In particular, we elaborate on one of the important ramifications of viewing genomic networks as being state-dependent, namely, their controllability during processes of genomic reorganization such as in cell differentiation.

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PMID:
21911407
[PubMed - indexed for MEDLINE]
PMCID:
PMC3198315
Free PMC Article

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