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Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0511, USA. thea.tlsty@ucsf.edu
Recently, in Nature Medicine, Schedin and colleagues define attributes within the involuting postpartum breast microenvironment that promote breast cancer metastasis. Cell invasiveness is controlled by a positive feedback loop involving COX-2 and fibrillar collagen. NSAIDs suppress tumor progression during postpartum involution, potentially providing effective agents for intervention in pregnant women.
Copyright © 2011 Elsevier Inc. All rights reserved.
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