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Cancer Cell. 2011 Sep 13;20(3):285-6. doi: 10.1016/j.ccr.2011.08.018.

Tissue states provide novel insights into attributes that drive metastasis.

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  • 1Helen Diller Comprehensive Cancer Center, University of California, San Francisco, CA 94143-0511, USA.


Recently, in Nature Medicine, Schedin and colleagues define attributes within the involuting postpartum breast microenvironment that promote breast cancer metastasis. Cell invasiveness is controlled by a positive feedback loop involving COX-2 and fibrillar collagen. NSAIDs suppress tumor progression during postpartum involution, potentially providing effective agents for intervention in pregnant women.

Copyright © 2011 Elsevier Inc. All rights reserved.

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