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Mol Pain. 2011 Sep 11;7:66. doi: 10.1186/1744-8069-7-66.

Generation and characterization of an Advillin-Cre driver mouse line.

Author information

  • 1Mouse Biology Unit, European Molecular Biology Laboratory, Via Ramarini 32, 00016 Monterotondo (Roma), Italy.

Abstract

Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouse line that expresses Cre-recombinase from the locus of the sensory neuron specific gene Advillin. These mice displayed almost exclusive Cre-mediated recombination in all peripheral sensory neurons. As such, the Advillin-Cre-driver line will be a powerful tool for targeting peripheral neurons in future investigations.

PMID:
21906401
[PubMed - indexed for MEDLINE]
PMCID:
PMC3185264
Free PMC Article

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