AIDS Res Hum Retroviruses. 2012 May;28(5):527-30. doi: 10.1089/AID.2011.0177. Epub 2011 Sep 23.

Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.

Ng OT, Eyzaguirre LM, Carr JK, Chew KK, Lin L, Chua A, Leo YS, Redd AD, Quinn TC, Laeyendecker O.

Source

Johns Hopkins School of Medicine, Johns Hopkins Medical Institution, Baltimore, MD, USA. oong@jhsph.edu

Abstract

A recent HIV-1 molecular epidemiology survey in Singapore identified a novel CRF01_AE/B recombinant form, which accounted for 13 (11.9%) of 109 patient samples. Peripheral blood mononuclear cell DNA from three of these 13 patients was used to generate near full-length sequences to characterize the novel CRF01_AE/B recombinant form. The three isolates had a recombinant structure composed of CRF01_AE and subtype B, and shared identical breakpoints. As the three patients were not epidemiologically linked, this recombinant form has been designated CRF51_01B. Identification of the novel recombinant forms indicates ongoing active HIV-1 transmission in Singapore.

PMID:: 21902588; [PubMed - indexed for MEDLINE]
PMCID:: PMC3332370

Free PMC Article

Images from this publication.See all images (3)Free text

MeSH Terms, Secondary Source ID

MeSH Terms

Secondary Source ID

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Supplemental Content

Save items

Click here to read article using PubReader

Related citations in PubMed

High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore. [BMC Infect Dis. 2013]
High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore.
Ng KY, Chew KK, Kaur P, Kwan JY, Khong WX, Lin L, Chua A, Tan MT, Quinn TC, Laeyendecker O, et al. BMC Infect Dis. 2013 Feb 19; 13:90. Epub 2013 Feb 19.
Emergence of HIV-1 CRF01_AE/B unique recombinant forms in Kuala Lumpur, Malaysia. [AIDS. 2005]
Emergence of HIV-1 CRF01_AE/B unique recombinant forms in Kuala Lumpur, Malaysia.
Tee KK, Pon CK, Kamarulzaman A, Ng KP. AIDS. 2005 Jan 28; 19(2):119-26.
Identification of a novel HIV type 1 circulating recombinant form (CRF52_01B) in Southeast Asia. [AIDS Res Hum Retroviruses. 2012]
Identification of a novel HIV type 1 circulating recombinant form (CRF52_01B) in Southeast Asia.
Liu Y, Li L, Bao Z, Li H, Zhuang D, Liu S, Wang X, Li T, Jia L, Yang S, et al. AIDS Res Hum Retroviruses. 2012 Oct; 28(10):1357-61. Epub 2012 Apr 5.
Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant forms. [AIDS Res Hum Retroviruses. 2011]
Molecular epidemiology of HIV type 1 in Singapore and identification of novel CRF01_AE/B recombinant forms.
Ng OT, Munshaw S, Lamers SL, Chew KK, Lin L, Redd AD, Manucci J, Quinn TC, Ray SC, Chua A, et al. AIDS Res Hum Retroviruses. 2011 Oct; 27(10):1135-7. Epub 2011 Feb 14.
Identification of a novel circulating recombinant form (CRF33_01B) disseminating widely among various risk populations in Kuala Lumpur, Malaysia. [J Acquir Immune Defic Syndr. 2...]
Identification of a novel circulating recombinant form (CRF33_01B) disseminating widely among various risk populations in Kuala Lumpur, Malaysia.
Tee KK, Li XJ, Nohtomi K, Ng KP, Kamarulzaman A, Takebe Y. J Acquir Immune Defic Syndr. 2006 Dec 15; 43(5):523-9.

See reviews... See all...

Cited by 4 PubMed Central articles

Molecular Diversity of HIV-1 among People Who Inject Drugs in Kuala Lumpur, Malaysia: Massive Expansion of Circulating Recombinant Form (CRF) 33_01B and Emergence of Multiple Unique Recombinant Clusters. [PLoS One. 2013]
Molecular Diversity of HIV-1 among People Who Inject Drugs in Kuala Lumpur, Malaysia: Massive Expansion of Circulating Recombinant Form (CRF) 33_01B and Emergence of Multiple Unique Recombinant Clusters.
Chow WZ, Ong LY, Razak SH, Lee YM, Ng KT, Yong YK, Azmel A, Takebe Y, Al-Darraji HA, Kamarulzaman A, et al. PLoS One. 2013; 8(5):e62560. Epub 2013 May 7.
High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore. [BMC Infect Dis. 2013]
High prevalence of CXCR4 usage among treatment-naive CRF01_AE and CRF51_01B-infected HIV-1 subjects in Singapore.
Ng KY, Chew KK, Kaur P, Kwan JY, Khong WX, Lin L, Chua A, Tan MT, Quinn TC, Laeyendecker O, et al. BMC Infect Dis. 2013 Feb 19; 13:90. Epub 2013 Feb 19.
Genome Sequences of a Novel HIV-1 Circulating Recombinant Form, CRF55_01B, Identified in China. [Genome Announc. 2013]
Genome Sequences of a Novel HIV-1 Circulating Recombinant Form, CRF55_01B, Identified in China.
Han X, An M, Zhang W, Cai W, Chen X, Takebe Y, Shang H. Genome Announc. 2013 Jan; 1(1). Epub 2013 Jan 24.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Identification of new CRF51_01B in Singapore using full genome analysis of three...
Identification of new CRF51_01B in Singapore using full genome analysis of three HIV type 1 isolates.
AIDS Res Hum Retroviruses. 2012 May ;28(5):527-30. doi: 10.1089/AID.2011.0177. Epub 2011 Sep 23 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: