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AIDS Res Hum Retroviruses. 2012 Jun;28(6):566-70. doi: 10.1089/AID.2011.0095. Epub 2011 Sep 27.

C868T single nucleotide polymorphism and HIV type 1 disease progression among postpartum women in Kenya.

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  • 1Department of Medicine, University of Washington, Seattle, Washington 98104, USA. ryc@u.washington.edu

Abstract

The C868T single nucleotide polymorphism in the CD4 receptor encodes an amino acid substitution of tryptophan for arginine in the third domain. Previous studies suggest that C868T increases the risk of HIV-1 acquisition; however, the influence of this single nucleotide polymorphism (SNP) on disease progression has not been established. The presence of the C868T polymorphism was not statistically significantly associated with HIV-1 disease progression outcomes in a cohort of postpartum Kenyan women.

PMID:
21902583
[PubMed - indexed for MEDLINE]
PMCID:
PMC3358105
Free PMC Article
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