Metastatic parathyroid carcinoma initially misdiagnosed as parathyroid adenoma: the role of parafibromin in increasing diagnostic accuracy

Intern Med J. 2011 Sep;41(9):695-9. doi: 10.1111/j.1445-5994.2011.02545.x.

Abstract

Parathyroid carcinoma, although a rare cause of primary hyperparathyroidism, carries a significant morbidity and mortality from severe symptomatic hypercalcaemia and related complications. We report a case where the diagnosis was not considered from the outset and review the current clinical and histopathological markers available to assist in the diagnosis of parathyroid carcinoma.

Publication types

  • Case Reports

MeSH terms

  • Adenoma / blood
  • Adenoma / diagnosis*
  • Adult
  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / physiology*
  • Diagnostic Errors*
  • Female
  • Humans
  • Parathyroid Neoplasms / blood
  • Parathyroid Neoplasms / diagnosis*
  • Parathyroid Neoplasms / secondary
  • Tumor Suppressor Proteins / blood
  • Tumor Suppressor Proteins / physiology*

Substances

  • Biomarkers, Tumor
  • CDC73 protein, human
  • Tumor Suppressor Proteins