Send to

Choose Destination
See comment in PubMed Commons below
Immunology. 2011 Oct;134(2):109-15. doi: 10.1111/j.1365-2567.2011.03472.x.

Are mouse models of human mycobacterial diseases relevant? Genetics says: 'yes!'.

Author information

  • 1Central Institute for Tuberculosis, Moscow, Russia.


Relevance and accuracy of experimental mouse models of tuberculosis (TB) are the subject of constant debate. This article briefly reviews genetic aspects of this problem and provides a few examples of mycobacterial diseases with similar or identical genetic control in mice and humans. The two species display more similarities than differences regarding both genetics of susceptibility/severity of mycobacterial diseases and the networks of protective and pathological immune reactions. In the opinion of the author, refined mouse models of mycobacterial diseases are extremely useful for modelling the corresponding human conditions, if genetic diversity is taken into account.

© 2011 The Author. Immunology © 2011 Blackwell Publishing Ltd.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley Icon for PubMed Central
    Loading ...
    Write to the Help Desk