Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nat Prod Res. 2012;26(11):1027-32. doi: 10.1080/14786419.2010.550263. Epub 2011 Sep 6.

In vitro antiviral activities of extracts derived from Daucus maritimus seeds.

Author information

  • 1Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences de Sfax- BP 1171, 3000 Sfax, Tunisia.

Abstract

The antiviral activities of extracts from Daucus maritimus seeds were investigated against the reverse transcriptase of human immunodeficiency virus (HIV) type 1 and a panel of RNA-dependent RNA polymerases of dengue virus, West Nile virus (WNV) and hepatitis C virus (HCV). The extracts showed moderate to potent inhibition rates against the four viral polymerases. The ethyl acetate extract exhibited a potent inhibitory effect against WNV's RdRp, with an IC₅₀ value of 8 µg mL⁻¹. The F₂ fraction exhibited potent inhibitory activity against WNV and HCV's RdRps, with IC₅₀ values 1 and 5 µg mL⁻¹, respectively. The P₂ fraction also showed potent inhibitory effects on WNV and HCV's RdRps, with IC₅₀ values 2.7 and 4 µg mL⁻¹, respectively. The results suggest that these extracts are candidates for the development of new anti-WNV RpDp and anti-HCV RpDp agents.

PMID:
21895456
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk