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J Cell Biol. 2011 Sep 5;194(5):669-78.

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia.

Windoffer R, Beil M, Magin TM, Leube RE.

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Institute of Molecular and Cellular Anatomy, RWTH Aachen University, 52057 Aachen, Germany.

Abstract

Epithelia are exposed to multiple forms of stress. Keratin intermediate filaments are abundant in epithelia and form cytoskeletal networks that contribute to cell type-specific functions, such as adhesion, migration, and metabolism. A perpetual keratin filament turnover cycle supports these functions. This multistep process keeps the cytoskeleton in motion, facilitating rapid and protein biosynthesis-independent network remodeling while maintaining an intact network. The current challenge is to unravel the molecular mechanisms underlying the regulation of the keratin cycle in relation to actin and microtubule networks and in the context of epithelial tissue function.

PMID:: 21893596; [PubMed - indexed for MEDLINE]
PMCID:: PMC3171125

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