Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Genet Dev. 2011 Oct;21(5):664-70. doi: 10.1016/j.gde.2011.08.005. Epub 2011 Sep 3.

Quantitative microscopy and imaging tools for the mechanical analysis of morphogenesis.

Author information

  • 1Department of Bioengineering, University of Pittsburgh, 3501 5th Avenue, Pittsburgh, PA 15213, United States. smt74@pitt.edu

Abstract

The importance of mechanical signals during embryogenesis and development, through both intercellular and extracellular signals, is coming into focus. It is widely hypothesized that physical forces help to guide the shape, cellular differentiation and the patterning of tissues. To test these ideas many classical engineering principles and imaging technologies are being adapted. Recent advances in microscopy, mechanical testing and genetic and pharmacological techniques, alongside computational models are helping to dissect the activity of mechanical signals in development at the cellular and molecular level. These inroads are providing maps of mechanical changes in tissue structure and stiffness, and will permit deeper insights into the role of mechanics in both developmental biology and disease.

Copyright © 2011 Elsevier Ltd. All rights reserved.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk