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Int J Biochem Cell Biol. 2011 Dec;43(12):1655-9. doi: 10.1016/j.biocel.2011.08.007. Epub 2011 Aug 24.

O-Acetylated peptidoglycan: controlling the activity of bacterial autolysins and lytic enzymes of innate immune systems.

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  • 1Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada.

Abstract

The O-acetylation of peptidoglycan is now known to occur in 50 different bacterial species, both Gram positive and Gram negative, including a number of important human pathogens. This modification to the essential cell wall component of bacteria provides both a level of control over endogenous autolysins and protection from the lysozymes of innate immune systems. In this review, we describe the details of the pathways for peptidoglycan O-acetylation that are now beginning to emerge and we explore the possibility that the associated enzymes may present new candidates for antibacterial targets.

Copyright © 2011 Elsevier Ltd. All rights reserved.

PMID:
21889603
[PubMed - indexed for MEDLINE]
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