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Clin Lymphoma Myeloma Leuk. 2011 Dec;11(6):490-7. doi: 10.1016/j.clml.2011.06.015. Epub 2011 Sep 1.

Ribosomal protein metallopanstimulin-1 impairs multiple myeloma CAG cells growth and inhibits fibroblast growth factor receptor 3.

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  • 1Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, USA.

Abstract

INTRODUCTION:

It was demonstrated that metallopanstimulin-1 (MPS-1, RPS27) inhibited the growth of tumors formed by head and neck squamous cell carcinoma cells and reduced paxillin gene expression.

METHODS:

The present study examined whether and how MPS-1 affects another type of cancer, multiple myeloma (CAG). Enhanced expression of MPS-1 dramatically inhibited CAG in vitro and in vivo.

RESULTS:

Overexpression of MPS-1 resulted in decreased fibroblast growth factor (FGF2) receptor 3 and impaired endogenous MAPK/ErK signaling. MAPK/ErK signaling was not stimulated by adding recombinant FGF2 to myeloma cells overexpressing MPS-1.

CONCLUSIONS:

These data suggest that MPS-1 suppresses CAG growth and that weakened FGF2 signaling may contribute to this effect.

Copyright © 2011 Elsevier Inc. All rights reserved.

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